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Coca wine

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Related Beverages:
Atlanta pharmacist John Pemberton developed Pembertons French Wine Coca based on Vin Mariani
– Popular among American consumers
– Georgia’s Prohibition in 1886 led Pemberton to replace wine with non-alcoholic syrup
– Resulting in the creation of Coca-Cola

Physiological Effects:
Cocaine and alcohol combination forms cocaethylene in the body
– Studies indicate cocaethylene decreases drunkenness feelings and enhances euphoric sensations
– Cocaethylene may be more cardiotoxic than cocaine or alcohol alone

– G. Harding’s book “A Wine Miscellany” published in 2005
– Information on Coca Wine from
– Study by Farooq, Bhatt, and Patel on neurotoxic and cardiotoxic effects of cocaine and ethanol
– Research by Farré et al. on alcohol and cocaine interactions in humans
– Wilson et al.’s study on cocaine, ethanol, and cocaethylene cardiotoxicity in an animal model

Additional Subtopics:
– Pemberton’s background as a pharmacist
– Evolution of Coca-Cola from Pembertons French Wine Coca
– Impact of Prohibition on beverage recipes
– Comparison of cocaethylene effects with cocaine and alcohol effects
– Importance of understanding physiological effects of cocaethylene

Significance of Research:
– G. Harding’s contribution to wine literature
– Insights from studies on neurotoxic and cardiotoxic effects of cocaine and ethanol
– Understanding interactions between alcohol and cocaine in humans
– Animal model research on cardiotoxicity of cocaine, ethanol, and cocaethylene
– Importance of academic studies in evaluating health impacts of substance interactions

Coca wine (Wikipedia)

Coca wine is an alcoholic beverage combining wine with cocaine. One popular brand was Vin Mariani, developed in 1863 by French-Corsican chemist and entrepreneur Angelo Mariani.

Coca wine
Advertising bill for the wine Mariani, lithograph of Jules Chéret, 1894
Country of origin France

At the end of the 19th century, the fear of drug abuse made coca-based drinks less popular. This led to the prohibition of cocaine in the United States in 1914 via the Harrison Narcotics Tax Act, and the removal of cocaine from coca wine, though coca leaf remained. Coca wine itself became illegal in the United States when its other main drug, alcohol, was banned just a few years later with the Eighteenth Amendment in 1920.

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